ABSTRACT
The resilience of a new national healthcare waste management protocol was compared in hospital and community settings in Ethiopia during the coronavirus disease 2019 (Covid-19) pandemic. The aim was also to evaluate the flexibility and implementation status of the guidelines for healthcare waste management in the context of a pandemic. The study was performed in a cross-sectional design by using a structured questionnaire and checklists and through a systematic review. Primary and secondary data were collected, including those from municipal sites, Yekatit 12 Hospital and other relevant stakeholders. Furthermore, the data were analysed and compared to the global practices and standards. The study revealed there was a comparable difference in the level of care taken in healthcare waste management between healthcare institutions and in the community in Addis Ababa city. The provision of awareness training to waste handlers in both the clinical and municipal setting was significantly deficient, which has to be addressed together with many other variables, starting with the formulation of a resilient waste management protocol. Furthermore, waste management protocols have to be expert-revised periodically. © 2023 ICE Publishing. All rights reserved.
ABSTRACT
1226 articles on privacy and COVID-19 were published by authors from 69 countries in this year's issue. COVID 19's privacy is now the focus of many researchers' attention. The present body of knowledge on privacy for COVID-19 digital technologies has been thoroughly analyzed, and a concise overview of research status and future developments can be gleaned. This paper conducted a bibliometric examination of privacy using the Scopus dataset. Utilizing VOSviewer software, the relevant literature papers published on this topic were examined to determine the field's development history, research hotspots, and future directions. Over time, there has been a rise in the number of studies published in privacy for COVID-19, particularly after 2020, and the growth rate has been steadily increasing. Regarding published research, the United States and China lead the pack. These articles appeared in primarily English-language journals and conference proceedings. Privacy and COVID-19 research was mostly computer science. The most used terms in privacy and COVID-19 were data privacy and humans. This paper examines the evolution of privacy and COVID-19 research and indicates current research priorities and future research goals. Furthermore, the privacy and COVID-19 study seem to be a promising sphere as this study identifies 26 domains. © 2023, Institute of Advanced Engineering and Science. All rights reserved.
ABSTRACT
1226 articles on privacy and COVID-19 were published by authors from 69 countries in this year's issue. COVID 19's privacy is now the focus of many researchers' attention. The present body of knowledge on privacy for COVID-19 digital technologies has been thoroughly analyzed, and a concise overview of research status and future developments can be gleaned. This paper conducted a bibliometric examination of privacy using the Scopus dataset. Utilizing VOSviewer software, the relevant literature papers published on this topic were examined to determine the field's development history, research hotspots, and future directions. Over time, there has been a rise in the number of studies published in privacy for COVID-19, particularly after 2020, and the growth rate has been steadily increasing. Regarding published research, the United States and China lead the pack. These articles appeared in primarily English-language journals and conference proceedings. Privacy and COVID-19 research was mostly computer science. The most used terms in privacy and COVID-19 were data privacy and humans. This paper examines the evolution of privacy and COVID-19 research and indicates current research priorities and future research goals. Furthermore, the privacy and COVID-19 study seem to be a promising sphere as this study identifies 26 domains. © 2023, Institute of Advanced Engineering and Science. All rights reserved.
ABSTRACT
Objective The objective of this study was to assess the attitude and hesitancy toward vaccine against COVID-19 in a Pakistani Population. Materials and methods A mix-method, prospective study was conducted and adults (aged ≥18 years) residing in Pakistan were invited to participate. The questionnaire was prepared, hosted in Google Forms and circulated through electronic platforms and was also available to be done in in-person. Data was compiled from 15th September to 30th November 2020. Results The response rate was 80%. A total of 1003 participants were included in the final analysis. Of them, 75% completed survey questionnaire online, while remaining 25% responded in-person. The mean age of the participants was 29.62 ± 10.47 years. The majority of participants were females;60.9% (n = 611). 57.02% (n = 572) of the participants were employed at the time of survey. Overall, 70.68% (n = 709) of the participants had previous experience of vaccines such as the flu vaccine Only 4.9% (n = 49) participants thought that they will be seriously ill from COVID-19 within six months and 39% (n = 392) participants were confident that they will get COVID-19. A total of 71.29% of the participants reported they would consider getting vaccinated once available. There was statistical association between gender and getting vaccinated (P < 0.001). Conclusion This study demonstrated that majority of the participants showed positive attitude toward considering COVID-19 vaccine. However awareness with informed knowledge of efficacy, possible adverse effects and cost would be of added great value to increase the real response of Pakistani population toward COVID-19 vaccination.
ABSTRACT
Background: COVID-19 pandemic has sent serious waves of medical emergency all over the world. Healthcare workers (HCWs) are vulnerable to the infection through various patient care processes. As the pandemic advances, it becomes necessary to screen the asymptomatic HCWs for COVID-19 as they constitute potential sources for the disease transmission. Objectives: To screen for the incidence of COVID-19 among asymptomatic HCWs in the tertiary care centers in the Southern regions of Saudi Arabia using both RT-PCR and serology. Methods: A cross-sectional, hospital-based study was conducted to determine the incidence of COVID-19 among the asymptomatic HCWs using RT-PCR and serological assays among 186 consented participants. Results: The total number of COVID-19 cases among the participants using all tests was 34 (18.3%). Out of the total participants, 4.8%, 3.2%, 7%, 10.2%, and 11.8% positive COVID-19 cases were detected using RT-PCR, rapid ICT for IgG, rapid ICT for IgM, ELISA for IgG and ELISA for IgM respectively. Significantly higher cases were observed among HCWs in the ICU of Aseer Central Hospital. 100% of the medical students and administrative staff, 40% of respiratory therapists, 31.8% of laboratory specialists, 22.7% of cleaners, 13.5% of physicians, 12.2% of nurses participated were positive to COVID-19. Participants of 18-24 years old showed the highest level of cases. However, considering the total number of positive COVID-19, nurses showed the highest number of cases. Conclusions: Considerable number of COVID-19 cases were detected among HCWs in the Southern region of KSA. Screening of HCWs should have the priority in the preventive interventions.
ABSTRACT
The new highly transmitted pathogenic viral infection started from Wuhan, China at the end of 2019. The World Health Organization publicized that it is phylogenetically belonging to severe acute respiratory syndrome (SARS), introduced as COVID-19 pandemic disease, and spread around the world. The first confirmed case in Kurdistan region was on 1st of March, 2020. While the first COVID-19 case in Halabja province/Kurdistan region was recorded on 27th of March, 2020. This study was designed, when the Wafa Hospital constructed in Halabja/Kurdistan region for infected patients. The data were collected from 14th April to the end of December, 2020 and included name and age of the infected persons. Samples were obtained nasopharyngeal using a sterilized swab following WHO guidelines and then the real time PCR (RT-PCR) machine was used for analysis. This study was particularly representing the impact of COVID-19 on suspected person. It was focused on the susceptibility of suspected cases in Halabja province, according to ages and sexes. During the study, 5183 cases were tested, 2796 (54%) cases were confirmed as positive result and 2387 (46%) cases were negative, including all ages, males and females. Confirmed male cases among 3116 cases were 1646 (60.1%), and 1150 (39.9%) positive cases recorded among 2067 female tests. In addition, the ages of the tested cases were divided into 10 sub-groups (0-9) years old to (90-99) years old, subsequently. The result of this study for both sexes, revealed that, the most confirmed cases among (30-39) years group and (40-49) years group were (1521) and (1223) confirmed positive cases. The lowest cases were among over 80 years old and below 9 years old (10, 3) confirmed cases. Besides, the confirmed cases for other age groups for both sexes were (50-59) years old was 397, (60-69) years old was 205, (70-79) was 77. Finally, the data showed that, the common confirmed cases were among groups 20-59 years old and the rare cases were under 9 and over 80 years.
ABSTRACT
The resilience of a new national healthcare waste management protocol was compared in hospital and community settings in Ethiopia during the Covid-19 pandemic. The aim was also to evaluate the flexibility and implementation status of the guidelines for healthcare waste management in the context of a pandemic. The study was performed in a cross-sectional design by using a structured questionnaire, checklists, and through a systematic review. Primary and secondary data were collected, including those from municipal sites, Yekatit 12 Hospital and other relevant stakeholders. Furthermore, the data were analysed and compared to the global practices and standards. The study revealed there was a comparable difference in the level of care taken during healthcare waste management between health care institutions and in the community in Addis Ababa city. Provision of awareness training to waste handlers in both the clinical and municipal setting were great deficiencies, which has to be addressed together with many other variables beginning from the formulation of a resilient waste management protocol. Furthermore, waste management protocols have to be expert-revised periodically. © 2022 ICE Publishing: All rights reserved.
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Interleukin 6 (IL-6) is an interleukin that works as a proinflammatory cytokine and as an anti-inflammatory myokine. The production of IL-6 in humans is under genetic control. IL-6 is a pleiotropic cytokine created in response to tissue injury and infections. IL-6 is one of the basic cytokines after stimulated macrophages. Hence, control of systemic IL-6 levels in SARS-CoV-2 infected patients may be a consideration for COVID-19 disease. This review will focus on the role of IL-6 in diagnosis and follow up of infection in addition to being the target for treatment. © 2022 Indian Society for Malaria and Communicable Diseases. All rights reserved.
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Many investigations have confirmed the link between a substance use disorder (SUD) and the COVID-19 pan-demic's increased risk of infection and consequences. This narrative review aims to understand these issues from a pharmacological standpoint, as well as the pan-demic's impact on forensic medicine. Research and review articles included in this review were selected through an extensive search of databases such as PubMed and the use of appropriate keywords e.g. “substance use disorder” and “COVID-19”. Due to a weakened immune system and degeneration of the respiratory system's defense systems, SUDs have been shown to increase the risk of COVID-19 infection. Furthermore, some substances raise pro-inflammatory mediators, exposing the body to a cytokine storm. SUD frequently causes secondary comorbidities, such as the liver, lung and cardiovascular disease, complicating the treatment of COVID-19 infections. Some misused substances can compromise the treatment's effectiveness or safety. This study also looked at the effects of the pandem-ic on forensic medicine. It underlines the importance of developing safe forensic examination procedures and methodologies during pandemics. The use of narcotic substances was documented as one of the reasons for the increase in the frequency of COVID-19 and the sever-ity of its repercussions. © 2021. AJFSFM.
ABSTRACT
Objective: The objective of this study was to assess the attitude and hesitancy toward vaccine against COVID-19 in a Pakistani Population. Materials and methods: A mix-method, prospective study was conducted and adults (aged ≥18 years) residing in Pakistan were invited to participate. The questionnaire was prepared, hosted in Google Forms and circulated through electronic platforms and was also available to be done in in-person. Data was compiled from 15th September to 30th November 2020. Results: The response rate was 80%. A total of 1003 participants were included in the final analysis. Of them, 75% completed survey questionnaire online, while remaining 25% responded in-person. The mean age of the participants was 29.62 ± 10.47 years. The majority of participants were females; 60.9% (n = 611). 57.02% (n = 572) of the participants were employed at the time of survey. Overall, 70.68% (n = 709) of the participants had previous experience of vaccines such as the flu vaccine Only 4.9% (n = 49) participants thought that they will be seriously ill from COVID-19 within six months and 39% (n = 392) participants were confident that they will get COVID-19. A total of 71.29% of the participants reported they would consider getting vaccinated once available. There was statistical association between gender and getting vaccinated (P < 0.001). Conclusion: This study demonstrated that majority of the participants showed positive attitude toward considering COVID-19 vaccine. However awareness with informed knowledge of efficacy, possible adverse effects and cost would be of added great value to increase the real response of Pakistani population toward COVID-19 vaccination.
Objetivo: El objetivo de este estudio fue evaluar la actitud y la renuencia hacia la vacuna frente a la COVID-19 en una población paquistaní. Materiales y métodos: Se realizó un estudio prospectivo de método mixto, invitándose a participar a personas adultas (edad ≥18 años) residentes en Paquistán. Se preparó el cuestionario, que se alojó en Google Forms y se hizo circular a través de plataformas electrónicas, pudiendo realizarse también de manera personal. Los datos se recopilaron desde el 15 de septiembre al 30 de noviembre de 2020. Resultados: La tasa de respuesta fue del 80%. El análisis final incluyó un total de 1.003 participantes, de los cuales el 75% completó el cuestionario-encuesta online, mientras que el 25% respondió en persona. La edad media de los participantes fue de 29,62 ± 10,47 años. La mayoría de los participantes eran mujeres: el 60,9% (n = 611). El 57,02% (n = 572) de los participantes tenía empleo en el momento de la encuesta. En general, el 70,68% (n = 709) de los participantes tenía experiencia previa sobre vacunas tales como la vacuna frente a la gripe. Solo el 4,9% (n = 49) de los participantes pensaba que padecerían la COVID-19 de forma grave en el plazo de seis meses, y el 39% (n = 392) de los participantes estaba seguro de que se contagiaría de dicha enfermedad. El 71,29% de los participantes reportó que consideraría recibir la vacuna una vez que se dispusiera de la misma. Existió una asociación estadística entre el sexo y el ser vacunado (P< 0,001). Conclusión: Este estudio demostró que la mayoría de los participantes mostró una actitud positiva hacia la consideración de la vacuna frente a la COVID-19. Sin embargo, la concienciación sobre el conocimiento informado de la vacuna, los posibles efectos adversos y el coste supondrían un gran valor añadido al incremento de la respuesta real de la población paquistaní hacia la vacuna frente a la COVID-19.
ABSTRACT
Background: COVID-19 is an ongoing viral pandemic caused by the SARS-COV-2 virus. Several drugs were repurposed for its management;however, most of these drugs were not ideal treatments by traditional methods of administration, whether given by injection or orally. This is due to many reasons including pharmacokinetic limitations or drug-induced adverse effects. There is an urgent need to develop these drugs to target the virus in the lung tissue through inhalation. Objective: To address the gap in knowledge regarding efficacy and safety of pulmonary drug delivery of repurposed antiviral against COVID-19. Findings: Ongoing trials for inhalable formulations of several drugs such as Niclosamide;Remdesivir, Hydroxychloroquine, and Azithromycin among others showed promising results. Conclusion: The development of pharmaceutical forms for inhaled administration of antiviral and anti-inflammatory drugs is an important direction that needs more attention to achieve the optimal management of respiratory infectious diseases.
ABSTRACT
COVID-19 is a pandemic viral pneumonia caused by beta-coronavirus SARS-CoV-2. It is associated with many complications including extreme systemic inflammatory response which eventually causes acute respiratory distress syndrome (ARDS), hypercoagulability, cytokine storm, failure of vital organs, and a high incidence of death. Bacterial secondary infection is possibly involved, in such cases, the role of antibiotics is justified. However, some antibiotics may have a role beyond the management of secondary infection. The current review discussed the potential antiviral effects of certain Fluoroquinolones (FQs) against SARS CoV-2 viruses. Several mechanisms such as targeting Main proteases and acting as zinc ionophore are discussed. Also explained their unique features, good access to lung tissues for suppression of inflammatory response via modulation of matrix metallopeptidases (MMPs) are explored. Their role in secondary infections, pharmacokinetics, and safety issues was briefly explored. The promising favorable features of FQs along with their efficacy in the management of secondary infections, highlights the need to consider these important antibiotics for more research as well as clinical trials in the management of COVID-19.
ABSTRACT
To support the manual contact tracing methods of Covid-19, countries and big companies like Apple and Google are busy developing several contact tracing applications. The purpose of digital contact tracing apps is to accelerate existing traditional face to face interview method which can control the pandemic effectively and rapidly. A major concern is whether consumers will be willing to download, install, and use the contact tracing applications because of the debate it created about its main attribute like security, privacy concern, system framework, data processing, location measurement. In this paper we discuss the contact tracing apps and its different architecture, then we analyze the framework in term of security, privacy concern and privacy policy. We reported 47 contact tracing applications which are from 28 countries worldwide, with several others expected to be roll out later. We found that 23 percent of contact tracing apps currently implemented do not provide privacy policy in their documentation. We believe that these comprehensive evaluation and specific suggestions will lead to creation and implementation of solutions towards Covid-19 and support governments and mobile development industries in creating safe and privacy conserving apps for contact tracing solutions. © 2021. All Rights Reserved.